The blood-brain barrier is incredibly good at protecting the brain from dangerous substances such as toxins and pathogens. However, when treating the brain with drugs for something like a brain tumour, it often becomes hard to navigate this restriction. Researchers from Yale have been investigating a method to ‘unlock’ this barrier, their findings offer a potential way of bypassing the blood-brain barrier.
What are the findings?
The research team from Yale have developed an antibody protein which could be used to ‘unlock’ the blood-brain barrier. Accessing the tumour site and bypassing the barrier for a couple of hours at a time would allow for the delivery of drugs to treat the brain.
Administering drugs in this way has been a goal in clinical research for a long time, and this is the first finding which will allow us to control the blood-brain barrier with a molecule.
The next steps include revisiting and assessing the effectiveness of this approach. This will shine a light on any safety issues with this method of treating patients. The team aims to expand their knowledge of how this may benefit other treatments such as chemotherapy. There is also potential for this antibody to be employed in treating other areas of the body as well.
For more scientific information on the study, click here.
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