Researchers from Tel Aviv University in Israel conducted a study focusing on eradicating specific brain cells that promote rapid tumour growth. The study found that, in animal models, Glioblastoma cells began to cease multiplying, massively improving survival.
How did the study work, and what did they find out?
In this study, researchers took a different approach to limiting the growth of Glioblastoma brain tumour cells. Usually, the focus would be on the tumour itself, but in this study the team targeted the supportive micro-environment.
The supportive micro-environment is the tissue surrounding the tumour. The team chose to focus on this area following the discovery that astrocytes, brain cells that usually support normal brain function, also promoted rapid tumour growth. With this discovery in mind, the researchers applied a unique method of eradicating these astrocytes. The results of this method showed dramatically positive outcomes in the lab.
In animal models, all animals survived the treatment with their tumour disappearing. Even those who had treatment discontinued mostly survived with no relapse.
This study was conducted using animal models, which is sometimes necessary to prove the efficacy of a treatment. The next steps would be creating an in-human trial to test the safety and effectiveness of a drug that could appropriately replicate this technique.
Researchers from the team believe prior data collected for Glioblastoma patients further support this idea, stating:
We found that patients with low expression of these identified genes lived longer, thus supporting the concept that the genes and processes identified are important to the survival of glioblastoma patients.
To read more about this study, click here.
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