A Spain-based research team are launching a clinical trial testing a new combination radiotherapy treatment for people with Glioblastomas. This phase I/II clinical trial will determine the safety and effectiveness of the drug ‘azeliragon’.
What else is there to know about the study?
Traditionally, standard care has seen radiotherapy as the most effective, accessible and widespread treatment for Glioblastoma patients. Unfortunately, however, many patients still do not benefit long-term from this standard care and their tumour continues to grow.
This study at the Spanish National Cancer Research Centre (CNIO) is repurposing the drug ‘Azeliragon’ to inhibit the body’s natural resistance to radiotherapy treatment. The study hopes to make the therapy even more effective. Previously, Azeliragon was researched for use in treating Alzheimer’s disease, but human trials found it was ineffective. Fortunately, the introduction of this drug into brain cancer research allows us to explore these alternative uses.
What to expect moving forward
Initial lab-based work using this drug to decrease ‘radio-resistance’ has been promising and had a relatively quick turn around and success rate compared to other studies using similar methods.
A lot of work is being done to test how we can make radiotherapy more effective. This method of improving care for the brain cancer community would be safe and easy to implement. More updates will be shared once the study has begun and results are published.
To read more scientific information, click here.
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