Researchers at the University of Colorado Cancer Centre have identified that infiltrative gliomas, on both the brain and spinal cord, are shaped by both the genetic evolution and the surrounding micro-environment.
More about the findings
In this study, the team in Colorado analysed the DNA sequencing of a cohort of 304 adults with IDH gliomas to determine how they grow at recurrence. The goal was to learn how we can adapt treatments to better improve the outcome for patients.
Three distinct observable traits were identified during the study. Each of them were then linked to specific characteristics of how the tumours recurred.
- Neuronal signalling activity: This being higher may contribute to tumour progression.
- Hypermutation: in some of the tumours, this was associated with rapid growth of the cancer cells.
- Increased stem-like neoplastic cell count: The growth of these cells reduced the overall survival rate for patients.
What does this mean for our community?
This additional knowledge of specific characteristics can help us to predict the progression of tumours and how they will grow and recur. In future studies aiming to develop treatments for gliomas, this research can be used to inform the trial design. This in turn can inform the best approach for helping our community to have better outcomes.
What to expect from specific types of tumours can only improve care for patients, allowing our specialists to make better informed decisions.
To read more about this study, click here.
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