Researchers in North Carolina, USA have utilised a method of cancer cell destruction in Glioblastoma by removing certain amino acids from the diet in animal models. This will hopefully lead to a clinical trial in humans.
What are the findings?
The lab research found that depriving cancer cells of the amino acids cysteine and methionine increased the likelihood of cell death through ‘ferroptosis’.
Ferroptosis is a form of cell death influenced by iron and lipid peroxide levels. It is distinctly different from forms of cell death we see in most other treatments.
The study found that the ferroptosis made chemotherapy drugs more effective, with low doses having much greater effects than before, resulting in improved overall survival.
The team are focusing on how they can now develop a trial for patients with Glioblastoma. The research team will determine and employ a specific diet prior to surgery, helping them learn how the human body and the tumour cells are affected.
After the surgery, the tumour can be analysed to learn more using various tests. This will be a great step forward in an area that interests so many in our community – does what we eat impact our condition, and can it positively impact on our outcomes?
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