Researchers at the Baylor College of Medicine in Texas have learned that brain tumours can interfere with how a Glioma patient’s neurons handle potassium. This disruption can lead to an increased likeliness of having seizures.
More about the study
The team reported in a journal called ‘Neuron’ that brain tumours can affect the ability of surrounding neurons in the brain to handle the ion ‘potassium’. This in turn can increase a person’s chance of having seizures.
The in-person trial used RNA sequencing alongside other techniques to analyse brain activity in Glioma patients. It showed that a gene called IGSF3 hinders the ability of astrocyte cells in the tumour site to take up potassium. This results in potassium accumulating, leading to seizures in the patient.
It is possible for other genes to uptake potassium in the brain. However, further study found that there is a major loss of these genes in tumour cells.
This study help us to understand why and how seizures occur for Glioma patients. We can expect future studies to explore how the uptake of potassium can be restored or improved to avoid the build up causing these devastating seizures.
Seizures are a terrible symptom which burdens our community. Improving treatment for patients who suffer from them would grant a much greater quality of life.
To read more scientific information, click here.
If you struggle with seizures, visit our page on epilepsy for more information and support on coping. Click here to visit the page.
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