Registered Charity No 1114634
Brain tumour clinical trials
available for:
All brain tumour types
| Relates to tumour types | Title of Research | Description | More information |
|---|---|---|---|
| Schwannoma Pituitary Paediatric Neuroblastoma oligoastrocytoma Ependymoma Meningioma Medulloblastoma Glioma Astrocytoma |
MOT – Identification and validating molecular targets in low grade brain tumours (Study ID: 16948) | A laboratory study using surplus tissue from all low grade brain tumours to discover and validate new molecular drug targets. read more | |
| Glioma Glioblastoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
Imaging in Transforming Gliomas (Study ID: 17381) | Gliomas are the commonest type of primary brain tumours accounting for approximately 70% of primary brain tumours in adults. Gliomas can be classified into two main... read more | |
| Glioma Glioblastoma Astrocytoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
MR characterisation of invasive phenotypes in GBMs (Study ID: 8596) | High grade gliomas are aggressive tumours that are usually rapidly fatal despite intensive treatment. If we could identify patients with limited spread, they might be... read more | |
| Glioblastoma Anaplastic astrocytoma |
TSPO PET Imaging in GBM – Imaging of the 18kDa Translocator Protein in Primary and Recurrent High-Grade Glioma using PET (Study ID: 33381) | The aim of this study is to evaluate whether the Positron Emission Tomography (PET) imaging of the Translocator Protein (TSPO) can predict tumour recurrence in... read more | |
| Paediatric |
CNS 2004 10 Functional Imaging of Tumours (for children and young adults with solid tumours) (Study ID: 1496) | 1) To develop functional imaging methods for the diagnosis, management and understanding of tumours in children and young people. 2) To correlate functional... read more | |
| Schwannoma Pituitary Paediatric Brain metastases Neuroblastoma oligoastrocytoma Ependymoma Meningioma Medulloblastoma Glioma Glioblastoma Astrocytoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
VoxTox - Linking radiation dose at the voxel level with toxicity (Study ID: 13716) | An observational study to collect detailed information about side effects for patients undergoing image-guided intensity-modulated radiotherapy to the head and neck,... read more | |
| Glioblastoma |
PARADIGM - Olaparib and radiotherapy in newly diagnosed glioblastoma (Study ID: 18137) | Short-course radiotherapy plus olaparib for newly diagnosed in patients unsuitable for radical chemoradiation: a randomised phase II clinical trial preceded by a... read more | |
| Pituitary |
A study looking at the genetics of pituitary gland (endocrine) tumours (Study ID: 4663) | A study aiming to find genes that may be important in the development of pituitary gland tumours. Participants will donate a blood sample to researchers for testing... read more | |
| Brain metastases |
CamBMT1 - Cambridge Brain Mets Trial 1 (Study ID: 17591) | In the past it has been found that many anti-cancer drugs are unable to cross over from the bloodstream into brain tumours because of a system called the blood brain... read more | |
| Glioblastoma |
Diffusion Imaging in Gliomas (Study ID: 17622) | Glioblastomas are the most common and aggressive type adult brain cancers, and the commonest cause of cancer death in women under 35 and men under 45. Average... read more | |
| Glioblastoma |
PRaM-GBM – Predicting sites of tumour progression in invasive margin of glioblastomas (Study ID: 32680) | Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. The predominant treatment is surgical removal... read more | |
| Glioblastoma |
PARADIGM-2 – A trial of olaparib with radiotherapy and chemotherapy for glioblastoma (Study ID: 33552) | The principle research questions are: Parallel 1 - In patients with newly diagnosed glioblastoma whose tumours are MGMT methylated, to establish the safety and... read more | |
| Brain metastases Glioblastoma |
AZD1390 given with radiation therapy (Study ID: 37040) | This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is... read more | |
| Glioblastoma Glioma |
Imaging Hypoxia in Cerebral Tumours (Study ID: 20704) | This is a study which will involve patients with a recently discovered brain lesion compatible with diagnosis of glioblastoma multiforme (GBM) and/or recurrent grade... read more | |
| Glioblastoma |
Imaging glioblastoma pH using CEST-MRI (Study ID: 35083) | Several studies have demonstrated that acidity within tumours is greater that in normal tissue. This effect is predominantly driven by the hypoxic (low oxygen)... read more | |
| Glioblastoma |
Investigating Zika Targeting of Glioma Stem Cells (Study ID: 38227) | We seek permission to analyse surplus specimens resected at craniotomy. We will first separate the tumour into single cells before infecting these specimens with Zika... read more | |
| Glioma |
VINILO – A trial of vinblastine and nilotinib for children and young people with a brain tumour (Study ID: 31853) | Low grade gliomas (LGG) are the most frequent brain tumour in children. More than 50% of these tumours will progress within the first 5 years and need further... read more | |
| Paediatric Glioma |
Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumours (Study ID: 34954) | A Phase 2 study that will assess the efficacy, safety and tolerability of pomalidomide in children and young adults aged 1 to < 21 years with recurrent or progressive... read more | |
| Glioma |
MISSION: GliomaS – A physiological exploratory study to assess tissue structure and metabolism in Glioma using sodium-23 Magnetic Resonance Imaging (23Na-MRI) (Study ID: 33936) | Cancer cells undergo a change in structure and an increase in metabolism that can be imaged using Sodium-23 magnetic resonance imaging (23Na-MRI), Hyperpolarized... read more | |
| Schwannoma Pituitary Brain metastases Neuroblastoma oligoastrocytoma Ependymoma Meningioma Medulloblastoma Glioma Glioblastoma Astrocytoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
Wrist Worn Trackers for monitoring physical activity in brain tumour patients (Study ID: 38629) | Most patient with brain tumours develop functional disturbance (weakness, balance problems, etc.) as part of their illness, and report fatigue as being a significant... read more | |
| Meningioma |
ROAM Radiation versus observation following surgery for atypical meningioma (Study ID: 30967) | Atypical meningioma is an intermediate grade brain tumour that arises from the linings of the brain. These are very rare tumours and there are approximately 150 new... read more | |
| Glioblastoma |
IceCAP-A Phase I trial of ipatasertib in combination with atezolizumab (Study ID: 37081) | This is a single centre, proof-of-concept phase I trial. The purpose of this study is to find out the side effects and safety of ipatasertib in combination with... read more | |
| Neuroblastoma |
My-CRA, Liquid 13 Cis Retinoic Acid (Study ID: 33256) | 13-CRA is used to treat some children with Neuroblastoma and other cancers, usually during the maintenance phase. Currently 13-CRA is only available in gelatin... read more | |
| Schwannoma Pituitary Brain metastases Neuroblastoma oligoastrocytoma Ependymoma Meningioma Medulloblastoma Glioma Glioblastoma Astrocytoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
MOLGEN – Molecular Genetics of Adverse Drug Reactions (Study ID: 8630) | Adverse drug reactions (ADR's) are a common cause of drug-related morbidity and may account for about 6.5% of all hospital admissions. A meta-analysis of studies... read more | |
| Schwannoma Pituitary Brain metastases Neuroblastoma oligoastrocytoma Ependymoma Meningioma Medulloblastoma Glioma Glioblastoma Astrocytoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
Establishing multipotent stem cell lines from CNS tumours (Study ID: 32706) | A striking feature of some central nervous system (CNS) tumours is the presence of cell types indicative of mixed neural/glial and mesodermal/mesenchymal (e.g.... read more | |
| Paediatric |
PROMOTE – Patient Reported Outcome Measures Online to Enhance Communication and Quality of Life (Study ID: 32866) | Is it feasible to ask children with brain tumours, and their parents, about their health, well-being, and concerns, online and then discuss this information with... read more | |
| Anaplastic astrocytoma Anaplastic glioma Anaplastic oligodendroglioma Astrocytoma Glioblastoma Glioma Medulloblastoma Meningioma Ependymoma oligoastrocytoma Neuroblastoma Brain metastases Pituitary Schwannoma |
Hyperpolarised 13C-Pyruvate MRI study (Study ID: 34177) | Metabolic changes related to disease are the precursor to anatomical changes in tissues. Currently our imaging methods routinely used in clinical practice look at the... read more | |
| Anaplastic glioma Anaplastic oligodendroglioma Glioblastoma Glioma |
Glutamate Dysfunction in Gliomas, V1.0 (Study ID: 35345) | Seizures are a frequent and serious problem for patients with brain tumours and are often not controlled with current best medical and surgical treatments. There are... read more | |
| Anaplastic glioma Anaplastic oligodendroglioma Glioblastoma Glioma |
Tissue-type MRI of brain tumours (Study ID: 35807) | Gliomas are the most common primary brain tumour. They can be “high-grade†with rapid growth and short patient survival times, or “low-gradeâ€... read more | |
| Anaplastic astrocytoma Anaplastic glioma Anaplastic oligodendroglioma Astrocytoma Glioblastoma Glioma Medulloblastoma Meningioma Ependymoma oligoastrocytoma Neuroblastoma Brain metastases Pituitary Schwannoma |
Identifying the origin of circulating DNA to detect and diagnose neuro (Study ID: 36279) | Damaged and dying cells release DNA into the circulation. This circulating, cell-free DNA (cfDNA) can be easily detected in blood and other bodily fluids such as... read more | |
| Paediatric |
ASPECT Study (Study ID: 36599) | Up to 70% of children with a tumour at the back of the brain (posterior fossa tumour) will have balance and coordination problems (known as ataxia), which have a... read more | |
| Anaplastic astrocytoma Anaplastic glioma Anaplastic oligodendroglioma Astrocytoma Glioblastoma Glioma Medulloblastoma Meningioma Ependymoma oligoastrocytoma Neuroblastoma Brain metastases Pituitary Schwannoma |
Harnessing plasticity to treat brain tumours (Study ID: 37315) | Brain tumours are hard to treat. They are not very sensitive to chemotherapy and radiotherapy. The main therapy is brain surgery to remove the tumour. Even if the... read more | |
| Glioblastoma |
BRITER study (Study ID: 38723) | Our aim with the BRITER study is to produce a way of predicting who might be more or less likely to suffer side effects from radiotherapy prior to starting treatment... read more | |
| Anaplastic astrocytoma Anaplastic glioma Anaplastic oligodendroglioma Astrocytoma Glioblastoma Glioma Medulloblastoma Meningioma Ependymoma oligoastrocytoma Neuroblastoma Brain metastases Pituitary Schwannoma |
HSI Neuro Phantom (Study ID: 38815) | Successful neurosurgery to remove brain tumours depends on achieving maximal safe tumour removal; avoiding damaging sensitive areas that undertake vital functions and... read more | |
| Schwannoma Pituitary Brain metastases Neuroblastoma oligoastrocytoma Ependymoma Meningioma Medulloblastoma Glioma Glioblastoma Astrocytoma Anaplastic oligodendroglioma Anaplastic glioma Anaplastic astrocytoma |
BT-LIFE – Brain Tumours, Lifestyle Interventions, and Fatigue Evaluations (Study ID: 38936) | 'BT-LIFE' stands for “Brain Tumours, Lifestyle Interventions, and Fatigue Evaluation." We aim to see if it is feasible to treat fatigue without using drugs, in... read more | |
| Ependymoma Paediatric |
SIOP Ependymoma II (Study ID: 38936) | The Ependymoma Program is a comprehensive program to improve the accuracy of the primary diagnosis of ependymoma and explore different therapeutic strategies in... read more | |
| Paediatric |
CMS Study – Cerebellar Mutism Syndrome in children with brain tumours of the posterior fossa (Study ID: 31760) | Central nervous system (CNS) tumours constitute 25% of all childhood cancers, and more than half of these are located in the cerebellum. One of the most troublesome... read more | |
| Paediatric Medulloblastoma |
PNET 5 (Study ID: 31891) | The PNET 5 study has been designed for children and young people aged from 3 yrs to 22 yrs with standard risk medulloblastoma who have undergone surgery to remove... read more | |
| Glioma |
Biomede – Biological Medicine for Diffuse Intrinsic Pontine Glioma (study ID: 33023) | Biomede is an international, multicenter, randomised, open-label, adaptive, phase II trial of treatment for Diffuse Intrinsic Pontine Glioma (DIPG). This trial... read more | |
| Glioblastoma |
IPI-GLIO immunotherapy trial | A Phase II, Open Label, Randomised Study of Ipilimumab with Temozolomide versus Temozolomide alone after surgery and chemoradiotherapy in patients with recently... read more |
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Registered Charity No 1114634
The Vera Wolstencroft Children And Animal Charitable Trust'
Registered Charity No 1114634
The Vera Wolstencroft Children And Animal Charitable Trust'