brainstrust brain tumour charity

Brain tumour clinical trials available for:
All brain tumour types

Relates to tumour types Title of Research Description More information
Medulloblastoma
Glioma
Astrocytoma
Meningioma
Ependymoma
oligoastrocytoma
Neuroblastoma
Paediatric
Pituitary
Schwannoma
Identification and validating molecular targets in low grade brain tumours A laboratory study using surplus tissue from all low grade brain tumours to discover and validate new molecular drug targets. read more
Glioblastoma
CRUKD/11/006: OPARATIC A Cancer Research UK Trial of olaparib (AZD2281), an oral PARP inhibitor, combined with extended low-dose oral temozolomide in patients with relapsed glioblastoma Interventional: drug. Glioblastoma multiforme (GBM) is the commonest and most aggressive primary brain tumour. Most tumours are resistant to current treatment.... read more
Glioma
CNS 2007 13 Translational Study for Children and Adolescents with Low Grade Glioma Observational. This study is looking at the family histories of children and young people who have been diagnosed with a low grade glioma. Researchers are trying to... read more
Glioblastoma
ISRCTN62033854 Magnetic resonance imaging to characterise invasive phenotypes in cerebral gliomas: an observational prospective cohort study An observational study using imaging. The spectrum of high grade gliomas invasion can be identified using diffusion tensor imaging (DTI). Combining these findings... read more
Ependymoma
Meningioma
Medulloblastoma
Glioma
Glioblastoma
Astrocytoma
Anaplastic oligodendroglioma
Anaplastic glioma
Anaplastic astrocytoma
CNS 2004 10 A study looking at functional imaging to help diagnose and treat children and young people with solid tumours This study is looking at functional imaging, using a range of scanning techniques to help diagnose, treat and understand more about solid tumours in children and... read more
Anaplastic astrocytoma
EORTC protocol 26053-22054 (BR14): A randomised controlled trial of temozolomide as adjuvant or concurrent treatment in anaplastic (WHO grade III) glioma Interventional. This trial is comparing radiotherapy alone with radiotherapy and temozolomide for a type of brain tumour called anaplastic glioma. ‘Anaplastic’... read more
Neuroblastoma
A trial looking at a drug called ch14.18/CHO for neuroblastoma in children and young people (GD2) This interventional trial is looking at different ways of giving a drug called ch14.18/CHO as treatment for neuroblastoma.  Neuroblastoma develops in specialised... read more
Ependymoma
Meningioma
Medulloblastoma
Glioma
Glioblastoma
Astrocytoma
Anaplastic oligodendroglioma
Anaplastic glioma
Anaplastic astrocytoma
Brightlight: The TYA Cancer Cohort Study This is an observational study to find out if young people who are diagnosed with cancer between the ages of 13 and 24 have different outcomes depending on where they... read more
Brain metastases
NCRN396: VE BASKET An open-label, phase II study of vemurafenib in patients with BRAF V600 mutation-positive cancers An open-label, phase II study of vemurafenib in patients with BRAF V600 mutation-positive cancers. This is for patients with brain metastases. Patients with brain... read more
Paediatric
SIOP CNS GCT II Prospective trial for the diagnosis of children, adolescents and young adults with intracranial germ cell tumours Malignant intracranial germ cell tumours (GCTs) are either germinoma or nongerminomatous GCTs (NGGCT). Germinoma can be cured by craniospinal irradiation (CSI) alone... read more
Glioblastoma
DCVax - Brain phase 3 clinical trial for patients with glioblastoma The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM for whom surgery is... read more
Brain metastases
WBRT post local treatment in melanoma study Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma – a randomised phase III trial The study looks at whether the addition of WBRT following excision/steriotactc irradiation will improve intracranial control and survival, without significant... read more
Brain metastases
HIPPO A randomsied phase 2 trial of Hippo Campal Sparing The purpose of this study is to evaluate whether sparing the hippocampi during whole brain radiotherapy following neurosurgery or stereotactic radiosurgery in... read more
Anaplastic astrocytoma
Anaplastic glioma
Astrocytoma
Glioblastoma
Glioma
Ependymoma
oligoastrocytoma
Hydroxycholoroquine Trial (HCQ) - S Short A randomised phase 2 trial investigating the additional benefit of hydroxychloroquine to short course radiotherapy in patients aged 70 years and older with high grade... read more
Anaplastic astrocytoma
Anaplastic glioma
Anaplastic oligodendroglioma
Astrocytoma
Glioblastoma
Glioma
Medulloblastoma
Meningioma
Ependymoma
oligoastrocytoma
Neuroblastoma
Brain metastases
Paediatric
Pituitary
Schwannoma
VoXtox - Linking radiation dose at the voxel level with Toxicity - N Burnet An observational study to collect detailed information about side effects for patients undergoing image-guided intensity-modulated radiotherapy to the head and neck,... read more
Paediatric
Enhanced occupational therapy for children with brain tumours A study to harmonise Occupational Therapy (OT) practise between two sites in preparation for multi-centre intervention study. There will be serial measurements of... read more
Anaplastic astrocytoma
Anaplastic glioma
Anaplastic oligodendroglioma
Astrocytoma
Glioblastoma
Glioma
Diffusion Imaging in Gliomas An observational study on the characterisation of treatment response using diffusion MR imaging. read more
Glioma
Glioblastoma
Improving the intra-operative diagnosis of high-grade glioma using a fluorescence biomarker Single arm surgical biomarker study. The trial is to investigate whether sampling visible tumour fluorescence improves the diagnostic accuracy during surgery. read more
Anaplastic astrocytoma
Anaplastic glioma
Anaplastic oligodendroglioma
Astrocytoma
Glioblastoma
Glioma
Translocator Protein Expression in Transforming Gliomas Non-randomised non-blinded pilot study. In gliomas, experimental and postmortem studies have shown increased expression of translocator protein (TSPO) within the... read more
Glioblastoma
PARADIGM - OlaPArib And RADiotherapy In newly-diagnosed GlioblastoMa Short-course radiotherapy plus olaparib for newly diagnosed in patients unsuitable for radical chemoradiation: a randomised phase II clinical trial preceded by a... read more
Pituitary
A study looking at the genetics of pituitary gland tumours A study aiming to find genes that may be important in the development of pituitary gland tumours. Participants will donate a blood sample to researchers for testing... read more
Glioma
Pilot study to develop methodology for 2-HG MRS in brain cancer Pilot study to develop methodology for 2-Hydroxyglutarate (2-HG) Magnetic resonance spectroscopy (MRS) read more
Astrocytoma
Glioma
Meningioma
Ependymoma
oligoastrocytoma
Neuroblastoma
Paediatric
Pituitary
Schwannoma
Identifying and validating molecular targets in low grade brain tumours Identifying and validating molecular targets in low grade brain tumours. read more
Anaplastic astrocytoma
Anaplastic glioma
Anaplastic oligodendroglioma
Astrocytoma
Glioblastoma
Glioma
Intraoperative Raman Spectroscopy for Immediate Human Brain Tumour Diagnosis and Detection of Tumour Margin Cancers are often impossible to visually distinguish from normal tissue. This is critical for brain cancer where residual invasive cancer cells frequently remain... read more
Anaplastic astrocytoma
Anaplastic glioma
Anaplastic oligodendroglioma
Astrocytoma
Glioblastoma
Glioma
Medulloblastoma
Meningioma
Ependymoma
oligoastrocytoma
Neuroblastoma
Brain metastases
Paediatric
Pituitary
Schwannoma
Spectral Analysis of Resected Brain Tissue Spectral Analysis of Resected Brain Tissue HypErspectraL Imaging Cancer Detection (HELICoiD A) read more
Anaplastic astrocytoma
Anaplastic glioma
Anaplastic oligodendroglioma
Astrocytoma
Glioblastoma
Glioma
Ependymoma
oligoastrocytoma
18F- Fluoromethylcholine (18F-FMC) PET/CT and magnetic resonance spectroscopy (MRS) Imaging and tissue biomarkers of cell membrane turnover in primary brain gliomas Gliomas are types of brain tumour, which are relatively uncommon compared with other cancers, but are the commonest cause of cancer death in women under 35 and men... read more
Brain metastases
CamBMT1 - Cambridge Brain Mets Trial 1 In the past it has been found that many anti-cancer drugs are unable to cross over from the bloodstream into brain tumours because of a system called the blood brain... read more
Meningioma
Trabectedin for Recurrent Grade II/III Meningioma EORTC This is a multicentre, interventional, randomized, open label and comparative phase II trial that will assess whether trabectedin shows antitumour activity in... read more

View by brain tumour type: All brain tumour types , Anaplastic astrocytoma, Anaplastic glioma, Anaplastic oligodendroglioma, Astrocytoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Ependymoma, oligoastrocytoma, Neuroblastoma, Brain metastases, Paediatric, Pituitary, Schwannoma